Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.64 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3046978 | 1.00 | HCRTR1 (0.64) | HCRTR1HCRTR2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3053244 | 0.92 | HCRTR1 (0.55) | HCRTR1HCRTR2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3057805 | 0.91 | HCRTR1 (0.54) | HCRTR1HCRTR2KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3040828 | 0.91 | HCRTR1 (0.54) | HCRTR1HCRTR2KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3049769 | 0.89 | HCRTR1 (0.52) | HCRTR1HCRTR2KMT2AALDH1A1NPC1 | |
| SCHEMBL2013190 | 0.89 | HCRTR1 (0.52) | HCRTR1HCRTR2KMT2AALDH1A1NPC1 | |
| SCHEMBL3058130 | 0.87 | HCRTR1 (0.59) | HCRTR1HCRTR2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3046975 | 0.87 | HCRTR1 (0.59) | HCRTR1HCRTR2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3048416 | 0.85 | HCRTR1 (0.51) | HCRTR1HCRTR2KMT2AMRGPRX4GPR132 | |
| SCHEMBL3058136 | 0.85 | HCRTR1 (0.51) | HCRTR1HCRTR2KMT2AMRGPRX4GPR132 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222396-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222396-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | CYP11B2, CYP11B1, BBC3 | HCRTR1 3230/4885HCRTR2 3029/4885KMT2A 3047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.