Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20472482 | 0.84 | PDE5A (0.46) | CHEK1 | |
| SCHEMBL26518454 | 0.83 | PDE5A (0.45) | CHEK1 | |
| SCHEMBL26506522 | 0.81 | SCD (0.41) | CHEK1 | |
| SCHEMBL15058349 | 0.78 | CHEK1 (0.51) | CHEK1CHRNB2CHRNA4 | |
| SCHEMBL15058351 | 0.78 | CHEK1 (0.51) | CHEK1CHRNB2CHRNA4 | |
| SCHEMBL20150369 | 0.77 | CHEK1 (0.59) | CHEK1 | |
| SCHEMBL20150279 | 0.76 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL20150697 | 0.75 | CHEK1 (0.80) | CHEK1 | |
| SCHEMBL23761231 | 0.75 | TBK1 (0.48) | CHEK1 | |
| SCHEMBL20150280 | 0.73 | CHEK1 (1.00) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295144-A1 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | UNIV ZHEJIANG (CN) | 2023-09-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295144-A1 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | CHEK1, PLK1, CHEK2 | CHEK1 1/4885CHRNB2 4501/4885CHRNA4 4239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.