Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15546267 | 0.95 | KMT2A (0.57) | KMT2AMEN1RXFP1MAPTHPGD | |
| SCHEMBL16893446 | 0.90 | MAPT (0.57) | KMT2AMEN1RXFP1MAPTHPGD | |
| SCHEMBL3060581 | 0.88 | KMT2A (0.49) | KMT2AMEN1RXFP1MAPTHPGD | |
| SCHEMBL16893457 | 0.87 | KMT2A (0.53) | KMT2AMEN1RXFP1MAPTHPGD | |
| SCHEMBL16904651 | 0.87 | MAPT (0.68) | KMT2AMEN1RXFP1MAPTHPGD | |
| SCHEMBL3053459 | 0.87 | MEN1 (0.50) | KMT2AMEN1RXFP1MAPTHPGD | |
| SCHEMBL15545992 | 0.86 | KMT2A (0.57) | KMT2AMEN1RXFP1MAPTHPGD | |
| SCHEMBL16893434 | 0.86 | MEN1 (0.57) | KMT2AMEN1RXFP1MAPTHPGD | |
| SCHEMBL15545878 | 0.86 | RXFP1 (0.75) | KMT2AMEN1RXFP1MAPTHPGD | |
| SCHEMBL15545929 | 0.84 | MEN1 (0.63) | KMT2AMEN1RXFP1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9777015-B2 | Useful thiophene derivatives in the treatment of diabetes | METABRAIN RESEARCH (FR) | 2017-10-03 | — | — | US | disclosed |
| US-9777015-B2 | Useful thiophene derivatives in the treatment of diabetes | METABRAIN RESEARCH (FR) | 2017-10-03 | — | — | US | disclosed |
| EP-2875010-B1 | THIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | METABRAIN RES (FR) | 2016-08-31 | — | — | EP | disclosed |
| US-20150197530-A1 | USEFUL THIOPHENE DERIVATIVES IN THE TREATMENT OF DIABETES | METABRAIN RESEARCH (FR) | 2015-07-16 | — | — | US | disclosed |
| US-20150197530-A1 | USEFUL THIOPHENE DERIVATIVES IN THE TREATMENT OF DIABETES | METABRAIN RESEARCH (FR) | 2015-07-16 | — | — | US | disclosed |
| US-8492428-B2 | Small-molecule botulinum toxin inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-07-23 | — | — | US | disclosed |
| US-20100260778-A1 | SMALL-MOLECULE BOTULINUM TOXIN INHIBITORS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100260778-A1 | SMALL-MOLECULE BOTULINUM TOXIN INHIBITORS | BTD, RAC2, BTN3A1 | KMT2A 3518/4885MEN1 3207/4885RXFP1 280/4885 |
| US-20150197530-A1 | USEFUL THIOPHENE DERIVATIVES IN THE TREATMENT OF DIABETES | SLC5A2, SLC5A1, TPMT | KMT2A 4602/4885MEN1 4184/4885RXFP1 3837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.