Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.44 |
| ▸ | EIF2AK4 | Q9P2K8 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376117 | 0.86 | RIPK1 (0.45) | KMT2ARIPK1SSTR4EIF2AK4KDM4E | |
| SCHEMBL16158619 | 0.76 | KDM4E (0.37) | KMT2AKDM4ELMNARAB9APARP1 | |
| SCHEMBL18372677 | 0.72 | SSTR4 (0.43) | RIPK1SSTR4EIF2AK4KDM4ELMNA | |
| SCHEMBL18366189 | 0.72 | SSTR4 (0.40) | KMT2ARIPK1SSTR4EIF2AK4KDM4E | |
| SCHEMBL16255866 | 0.71 | SSTR4 (0.50) | KMT2ARIPK1SSTR4EIF2AK4KDM4E | |
| SCHEMBL5768245 | 0.70 | EIF2AK4 (0.47) | KMT2AEIF2AK4 | |
| SCHEMBL31475516 | 0.69 | KDM4E (0.41) | KMT2AKDM4EPARP1 | |
| SCHEMBL20455586 | 0.69 | KDM4E (0.47) | KMT2ASSTR4KDM4ERAB9A | |
| SCHEMBL16256102 | 0.66 | SSTR4 (0.61) | RIPK1SSTR4EIF2AK4LMNA | |
| SCHEMBL1996711 | 0.65 | KMT2A (1.00) | KMT2AKDM4EABL1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |