Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 9/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13996942 | 0.68 | TRPA1 (0.57) | TRPA1MAPTMEN1HTTKMT2A | |
| SCHEMBL11165330 | 0.67 | MAPT (0.46) | TRPA1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL9232229 | 0.67 | TRPA1 (0.55) | TRPA1MAPTMEN1HTTKMT2A | |
| SCHEMBL22001 | 0.66 | TRPA1 (0.43) | TRPA1MAPTMEN1HTTKMT2A | |
| Dibenzo[B,F][1,4]Oxazepine SCHEMBL123289 | 0.64 | TRPA1 (1.00) | TRPA1MAPTMEN1HTTKMT2A | |
| SCHEMBL8120117 | 0.63 | TRPA1 (0.61) | TRPA1MAPTMEN1HTTKMT2A | |
| SCHEMBL3092641 | 0.63 | TRPA1 (0.41) | TRPA1CYP1A2CYP2D6KDM4ELMNA | |
| SCHEMBL692060 | 0.63 | TRPA1 (0.41) | TRPA1CYP1A2CYP2D6 | |
| Dibenzo[B,F][1,4]Oxazepine SCHEMBL30601896 | 0.63 | TRPA1 (0.96) | TRPA1MAPTMEN1HTTKMT2A | |
| SCHEMBL10193002 | 0.61 | TRPA1 (0.53) | TRPA1MAPTMEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |