Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 15/20 | 0.63 |
| ▸ | CTPS2 | Q9NRF8 | 2/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21076844 | 0.88 | CTPS1 (0.65) | CTPS1CTPS2ALDH1A1 | |
| SCHEMBL21044575 | 0.84 | CTPS1 (0.60) | CTPS1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL24088748 | 0.83 | CTPS1 (0.55) | CTPS1CTPS2HSD11B1 | |
| SCHEMBL21044274 | 0.83 | CTPS1 (0.59) | CTPS1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL29791239 | 0.80 | CTPS1 (0.57) | CTPS1CSNK2A1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL21044371 | 0.80 | CTPS1 (0.55) | CTPS1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL23139977 | 0.78 | CTPS1 (0.53) | CTPS1CTPS2 | |
| SCHEMBL21077097 | 0.78 | CTPS1 (0.80) | CTPS1CTPS2 | |
| SCHEMBL21044107 | 0.76 | CTPS1 (0.58) | CTPS1CTPS2 | |
| SCHEMBL22490773 | 0.74 | CTPS1 (0.50) | CTPS1CTPS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023166077-A1 | COMBINATION OF A CTPS1 INHIBITOR AND A ATR INHIBITOR IN CANCER THERAPY | STEP PHARMA S.A.S. (FR) | 2023-09-07 | — | — | WO | disclosed |