Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 6/20 | 0.42 |
| ▸ | IKZF2 | Q9UKS7 | 4/20 | 0.42 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26135459 | 1.00 | CRBN (0.46) | CRBNDDB1CSNK1A1IKZF2GSPT1 | |
| SCHEMBL26133901 | 0.88 | CRBN (0.51) | CRBNCSNK1A1IKZF2GSPT1 | |
| SCHEMBL30591763 | 0.86 | CRBN (0.52) | CRBNIKZF2 | |
| SCHEMBL26134083 | 0.85 | CRBN (0.61) | CRBNIKZF2 | |
| Formic Acid SCHEMBL26133947 | 0.83 | CRBN (0.56) | CRBNCSNK1A1IKZF2 | |
| SCHEMBL30570135 | 0.82 | CRBN (0.45) | CRBNDDB1CSNK1A1IKZF2GSPT1 | |
| SCHEMBL30729349 | 0.82 | CRBN (0.45) | CRBNDDB1CSNK1A1IKZF2GSPT1 | |
| SCHEMBL31736558 | 0.82 | CRBN (0.48) | CRBNDDB1CSNK1A1IKZF2 | |
| SCHEMBL30746199 | 0.81 | CRBN (0.47) | CRBNDDB1CSNK1A1IKZF2 | |
| SCHEMBL30591547 | 0.81 | CRBN (0.53) | CRBNIKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260028354-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENT OF THE UNIV OF MICHIGAN (US) | 2026-01-29 | — | — | US | disclosed |
| US-20250195484-A1 | CEREBLON LIGANDS AND USES THEREOF | UNIV MICHIGAN (US) | 2025-06-19 | — | — | US | disclosed |
| EP-4554948-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Regents of the University of Michigan (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024015409-A1 | CHROMAN DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-01-18 | — | — | WO | disclosed |
| WO-2023201012-A1 | IKZF2 DEGRADERS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-10-19 | — | — | WO | disclosed |
| WO-2023183607-A1 | CEREBLON LIGANDS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250195484-A1 | CEREBLON LIGANDS AND USES THEREOF | CRBN, CDR2, CHLSN | CRBN 1/4885DDB1 2913/4885CSNK1A1 359/4885 |
| US-20260028354-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ESRRA, ESR2, ESRRB | CRBN 524/4885DDB1 1861/4885CSNK1A1 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.