Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3045981 | 0.94 | HDAC6 (0.47) | HDAC6CHRNA7HTR1AHTR2AHTR2C | |
| SCHEMBL3182417 | 0.92 | HDAC6 (0.56) | HDAC6CHRNA7POLB | |
| SCHEMBL3055179 | 0.88 | HDAC6 (0.55) | HDAC6CHRNA7POLB | |
| SCHEMBL3051389 | 0.87 | HDAC6 (0.51) | HDAC6CHRNA7HTR1APOLB | |
| SCHEMBL3055770 | 0.86 | HDAC6 (0.53) | HDAC6CHRNA7POLB | |
| SCHEMBL3054092 | 0.86 | HDAC6 (0.53) | HDAC6CHRNA7 | |
| SCHEMBL3054425 | 0.79 | CA9 (0.54) | HDAC6HTR1APOLB | |
| SCHEMBL3171208 | 0.77 | POLB (0.56) | HDAC6POLB | |
| SCHEMBL3051083 | 0.76 | HTR2A (0.54) | CHRNA7HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL3058816 | 0.75 | CA2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394825-B2 | Compound | STERIX LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | disclosed |
| EP-2155192-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | Sterix Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008117061-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222299-A1 | COMPOUND | MKI67, VHL, MYC | HDAC6 540/4885CHRNA7 4760/4885HTR1A 1761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.