Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 5/20 | 0.35 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20241345 | 1.00 | GABRA1 (0.46) | GABRA1GPBAR1RETBMP1NR1H4 | |
| SCHEMBL30592795 | 0.84 | GABRA1 (0.47) | GABRA1GPBAR1BMP1 | |
| SCHEMBL20241238 | 0.84 | GABRA1 (0.47) | GABRA1GPBAR1BMP1 | |
| SCHEMBL20241248 | 0.77 | GABRA1 (0.51) | GABRA1RETBMP1NR1H4PTGDR2 | |
| SCHEMBL30592842 | 0.77 | GABRA1 (0.51) | GABRA1RETBMP1NR1H4PTGDR2 | |
| SCHEMBL17358926 | 0.75 | GPBAR1 (0.50) | GPBAR1NR1H4 | |
| SCHEMBL21590936 | 0.75 | GABRA1 (0.48) | GABRA1RETNR1H4PTGDR2 | |
| SCHEMBL1930966 | 0.75 | KMT2A (0.48) | GPBAR1NR1H4 | |
| SCHEMBL28326019 | 0.74 | IP6K1 (0.37) | GPBAR1RETNR1H4HCAR2 | |
| SCHEMBL18984612 | 0.72 | BRD4 (0.40) | GPBAR1RETHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117285525-A | Novel isoxazolyl ether derivatives as GABAA alpha 5PAM | 豪夫迈·罗氏有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-109923113-B | Isoxazolyl ether derivatives as GABA A alpha 5 PAM | 豪夫迈·罗氏有限公司 | 2023-10-13 | — | — | CN | disclosed |