Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11626481 | 1.00 | MAPT (0.45) | MAPTPOLBADORA3ALDH1A1KDM4E | |
| SCHEMBL2574309 | 0.82 | MAPT (0.41) | MAPTPOLBALDH1A1KDM4ENPSR1 | |
| SCHEMBL11614853 | 0.80 | TDP1 (0.39) | MAPTPOLBALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL31336329 | 0.78 | ADORA3 (0.48) | MAPTPOLBADORA3ALDH1A1KDM4E | |
| SCHEMBL26608431 | 0.78 | ADORA3 (0.48) | MAPTPOLBADORA3ALDH1A1KDM4E | |
| SCHEMBL30593158 | 0.75 | POLB (0.42) | MAPTPOLBADORA3ALDH1A1KDM4E | |
| SCHEMBL11628165 | 0.75 | POLB (0.42) | MAPTPOLBADORA3ALDH1A1KDM4E | |
| SCHEMBL14183027 | 0.75 | ADORA3 (0.50) | MAPTPOLBADORA3ALDH1A1KDM4E | |
| SCHEMBL9270724 | 0.73 | POLB (0.47) | MAPTPOLBADORA3ALDH1A1KDM4E | |
| SCHEMBL11728849 | 0.73 | KDM4E (0.46) | MAPTPOLBALDH1A1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4511115-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | Vertex Pharmaceuticals Incorporated (US) | 2025-02-26 | — | — | EP | disclosed |
| WO-2023205468-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |