Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 6/20 | 0.64 |
| ▸ | DDO | Q99489 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | AHR | P35869 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | CDC25C | P30307 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26608351 | 1.00 | DAO (0.64) | DAODDOKDM4EFLT3AKR1B1 | |
| SCHEMBL19126568 | 0.85 | DAO (0.64) | DAODDOKDM4EFLT3AHR | |
| SCHEMBL4778716 | 0.81 | DAO (0.68) | DAODDOKDM4EFLT3AKR1B1 | |
| SCHEMBL16627567 | 0.81 | METAP2 (0.46) | DAODDOFLT3AHR | |
| SCHEMBL3395521 | 0.78 | DAO (1.00) | DAODDOKDM4EFLT3 | |
| SCHEMBL12970589 | 0.78 | DAO (0.64) | DAODDOKDM4EFLT3AKR1B1 | |
| SCHEMBL31378775 | 0.78 | DAO (0.64) | DAODDOKDM4EFLT3AKR1B1 | |
| SCHEMBL2463866 | 0.78 | DAO (0.64) | DAOAKR1B1AHRPARP1 | |
| SCHEMBL16627575 | 0.78 | DAO (0.64) | DAODDOKDM4EFLT3AKR1B1 | |
| SCHEMBL8871521 | 0.77 | DAO (0.62) | DAODDOKDM4EFLT3AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4511116-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | Vertex Pharmaceuticals Incorporated (US) | 2025-02-26 | — | — | EP | disclosed |
| EP-4511115-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | Vertex Pharmaceuticals Incorporated (US) | 2025-02-26 | — | — | EP | disclosed |
| WO-2023205463-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |
| WO-2023205468-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |