Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.60 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14739313 | 1.00 | MAOA (0.68) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL14755353 | 0.87 | MAOA (0.51) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL17381541 | 0.86 | KDM4E (0.70) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL11715443 | 0.85 | MAPK10 (0.65) | KDM4EALDH1A1GLARCE1CHRNA7 | |
| SCHEMBL7987730 | 0.85 | KDM4E (0.68) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL11719015 | 0.85 | MAPK10 (0.65) | KDM4EALDH1A1GLARCE1CHRNA7 | |
| Hydrochloric Acid SCHEMBL11713492 | 0.84 | MAPK10 (0.63) | KDM4EALDH1A1MAPTGLARCE1 | |
| SCHEMBL1148346 | 0.82 | MAOA (1.00) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL11240914 | 0.82 | RAD52 (0.72) | KDM4EALDH1A1GLARCE1CHRNA7 | |
| SCHEMBL18736054 | 0.82 | RAD52 (0.69) | KDM4EALDH1A1GLARCE1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155192-B1 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LTD (GB) | 2016-09-28 | — | — | EP | disclosed |
| US-8394825-B2 | Compound | STERIX LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| US-8394825-B2 | Compound | STERIX LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | disclosed |
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | disclosed |
| EP-2155192-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | Sterix Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008117061-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222299-A1 | COMPOUND | MKI67, VHL, MYC | MAOA 2205/4885KDM4E 1083/4885ALDH1A1 1517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.