Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.40 |
| ▸ | FLT3 | P36888 | 9/20 | 0.40 |
| ▸ | KIT | P10721 | 8/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | LTK | P29376 | 2/20 | 0.40 |
| ▸ | GRK5 | P34947 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | MST1R | Q04912 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30595391 | 0.83 | KDR (0.32) | KDRFLT3KITAURKBMET | |
| SCHEMBL22304364 | 0.75 | KDR (0.50) | KDRFLT3KITAURKBMET | |
| SCHEMBL8524531 | 0.72 | NR1I2 (0.45) | NR1I2 | |
| SCHEMBL29814520 | 0.71 | ADA (0.39) | FAAHDHFRNR1I2 | |
| SCHEMBL29745185 | 0.71 | NR1I2 (0.40) | NR1I2 | |
| SCHEMBL29744995 | 0.70 | NR1I2 (0.42) | DHFRNR1I2 | |
| SCHEMBL7104911 | 0.70 | NR1I2 (0.42) | DHFRNR1I2 | |
| SCHEMBL10633096 | 0.70 | NR1I2 (0.42) | DHFRNR1I2 | |
| SCHEMBL19695714 | 0.68 | KDR (0.50) | KDRFLT3KITAURKBMET | |
| SCHEMBL29814823 | 0.68 | NOS2 (0.39) | DHFREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116804005-A | Kinesin KIF18A inhibitor and application thereof | 上海湃隆生物科技有限公司 | 2023-09-26 | — | — | CN | disclosed |