Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.47 |
| ▸ | PLK4 | O00444 | 4/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | ETV6 | P41212 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.41 |
| ▸ | HAMP | P81172 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24418440 | 1.00 | TNKS (0.47) | TNKSPLK4FLT3AURKAACVR1 | |
| SCHEMBL24418315 | 0.91 | TNKS (0.46) | TNKSPLK4FLT3AURKAACVR1 | |
| SCHEMBL29606913 | 0.91 | TNKS (0.46) | TNKSPLK4FLT3AURKAACVR1 | |
| SCHEMBL24418581 | 0.90 | PLK4 (0.43) | TNKSPLK4FLT3AURKAACVR1 | |
| SCHEMBL30596028 | 0.89 | ACVR1 (0.44) | TNKSPLK4FLT3AURKAACVR1 | |
| Bromide SCHEMBL30596073 | 0.89 | PLK4 (0.42) | TNKSPLK4FLT3AURKAACVR1 | |
| Bromide SCHEMBL25412582 | 0.89 | PLK4 (0.42) | TNKSPLK4FLT3AURKAACVR1 | |
| SCHEMBL24418584 | 0.89 | ACVR1 (0.44) | TNKSPLK4FLT3AURKAACVR1 | |
| SCHEMBL24418312 | 0.89 | MAP4K1 (0.49) | PLK4FLT3AURKAACVR1MAP4K1 | |
| SCHEMBL29607829 | 0.89 | MAP4K1 (0.49) | PLK4FLT3AURKAACVR1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4223759-B1 | PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | BROADENBIO CO LTD (CN) | 2025-06-11 | — | — | EP | claimed |
| US-20230322789-A1 | PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | BROADENBIO CO., LTD. (CN) | 2023-10-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322789-A1 | PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | PDXK, CMPK1, GCK | TNKS 200/4885PLK4 40/4885FLT3 1805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.