Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 5/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | G6PD | P11413 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL622763 | 1.00 | NQO2 (0.55) | NQO2KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL24005897 | 0.86 | PDGFRB (0.52) | NQO2KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL3701516 | 0.78 | MAPT (0.47) | NQO2KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL10780561 | 0.77 | MEN1 (0.52) | NQO2KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL28783508 | 0.76 | KDM4E (0.51) | MEN1KMT2AMAPTPOLBRAB9A | |
| SCHEMBL3731976 | 0.76 | NQO2 (0.88) | NQO2KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL30363708 | 0.76 | NQO2 (0.88) | NQO2KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL96953 | 0.75 | SYK (0.57) | KMT2AMAPTLMNAALDH1A1KDM4E | |
| SCHEMBL29096082 | 0.75 | SYK (0.57) | KMT2AMAPTLMNAALDH1A1KDM4E | |
| SCHEMBL170428 | 0.75 | MEN1 (0.68) | MEN1KMT2AMAPTPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4504730-A1 | DISCOVERY OF COVALENT EGFR INHIBITOR THROUGH CYSTEINE 775 | Dana-Farber Cancer Institute, Inc. (US) | 2025-02-12 | — | — | EP | disclosed |
| WO-2023196409-A1 | DISCOVERY OF COVALENT EGFR INHIBITOR THROUGH CYSTEINE 775 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-12 | — | — | WO | disclosed |