SCHEMBL170428

SCHEMBL170428

COc1cccc2cccnc12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 7/20 0.68
KMT2A Q03164 7/20 0.68
RAB9A P51151 5/20 0.68
LMNA P02545 4/20 0.68
SMN1; SMN2 Q16637 4/20 0.68
NPC1 O15118 3/20 0.68
PDE10A Q9Y233 1/20 0.66
KDM4E B2RXH2 4/20 0.58
MCHR1 Q99705 1/20 0.56
MAPT P10636 5/20 0.54
GAA P10253 2/20 0.54
HTT P42858 2/20 0.54
GMNN O75496 1/20 0.54
TP53 P04637 1/20 0.54
HSP90AA1 P07900 1/20 0.54
MMP2 P08253 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2D6 P10635 1/20 0.54
MMP9 P14780 1/20 0.54
ALOX15 P16050 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30614510 1.00 MEN1 (0.68) MEN1KMT2ARAB9ALMNASMN1; SMN2
Hydrochloric Acid SCHEMBL6418353 0.98 MEN1 (0.66) MEN1KMT2ARAB9ALMNASMN1; SMN2
Water SCHEMBL10865815 0.98 MEN1 (0.66) MEN1KMT2ARAB9ALMNASMN1; SMN2
Ethane SCHEMBL27458330 0.98 MEN1 (0.66) MEN1KMT2ARAB9ALMNASMN1; SMN2
SCHEMBL28259240 0.91 MEN1 (0.59) MEN1KMT2ARAB9ALMNASMN1; SMN2
Toluene SCHEMBL27569075 0.89 LMNA (0.57) MEN1KMT2ARAB9ALMNASMN1; SMN2
Acetic Acid SCHEMBL8159401 0.89 PDE10A (0.60) MEN1KMT2ARAB9ALMNASMN1; SMN2
SCHEMBL27453447 0.89 RAB9A (0.61) MEN1KMT2ARAB9ALMNASMN1; SMN2
SCHEMBL8928619 0.86 MEN1 (0.54) MEN1KMT2ARAB9ALMNASMN1; SMN2
SCHEMBL12926855 0.85 PDE10A (0.59) MEN1KMT2ARAB9ALMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2568 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117205211-B Application of quinoline compound in preparation of fish parasitic protozoan resisting medicine 西北农林科技大学深圳研究院 2024-04-05 CN claimed
CN-117205211-A Application of quinoline compound in preparation of fish parasitic protozoan resisting medicine 西北农林科技大学深圳研究院 2023-12-12 CN claimed
CN-114105984-B Method for preparing indolizine type corrosion inhibitor 中国石油大学(华东) 2023-08-25 CN claimed
EP-3252037-B1 PROCESS FOR THE PREPARATION OF (3Z,5S)-5-(HYDROXYMETHYL)-1-[(2´-METHYL-1,1´-BIPHENYL-4-YL)CARBONYL)PYRROLIDIN-3-ONE O-METHYLOXIME ObsEva SA (CH) 2022-03-09 EP claimed
CN-114105984-A Preparation method of indolizine corrosion inhibitor 中国石油大学(华东) 2022-03-01 CN claimed
CN-107674073-B 3, 5-disubstituted-3H-imidazo [4,5-B ] pyridine compounds as modulators of protein kinases 印蔻真治疗公司 2021-09-10 CN claimed
CN-112945948-A Application of nitrogen-oxygen free radical compound as stabilizer in preparation of urine occult blood test paper 迪瑞医疗科技股份有限公司 2021-06-11 CN claimed
EP-3815687-A1 THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, FIBROTIC DISEASES, AND CANCER DISEASES Meiji Seika Pharma Co., Ltd. (JP) 2021-05-05 EP claimed
CN-110759952-B Cobalt complex constructed based on 8-methoxyquinoline and preparation method and application thereof 广西师范大学 2021-04-20 CN claimed
CN-110642875-B Copper complex constructed based on 8-methoxyquinoline and preparation method and application thereof 广西师范大学 2021-02-09 CN claimed
EP-0366561-A2 1-Azabicycloalkane derivatives, process for their preparation and their use as medicines ROUSSEL-UCLAF (FR) 1990-05-02 EP claimed
EP-0338723-A1 Novel compounds BEECHAM GROUP PLC (GB) 1989-10-25 EP claimed
US-4786648-A ANALGESIC WARNER-LAMBERT COMPANY (US) 1988-11-22 US claimed
WO-1988008836-A2 ARYL SUBSTITUTED NAPHTHALENE, BENZOXEPINE, BENZAZEPINE, BENZOCYCLOHEPTENE DERIVATIVES SCHERING CORPORATION (US) 1988-11-17 WO claimed
EP-0271798-A2 O-Substituted tetrahydropyridine oxime cholinergic agents WARNER-LAMBERT COMPANY (US) 1988-06-22 EP claimed
US-4710508-A ANALGESICS WARNER-LAMBERT COMPANY (US) 1987-12-01 US claimed
EP-0241043-A2 Novel diarylalkanoids having activity as lipoxygenase inhibitors WARNER-LAMBERT COMPANY (US) 1987-10-14 EP claimed
EP-0043469-B1 INTERFERENCE-RESISTANT TEST DEVICE FOR DETERMINING A PEROXIDATIVELY ACTIVE SUBSTANCE IN A TEST SAMPLE AND METHOD FOR PREPARING IT MILES LABORATORIES, INC. (US) 1985-01-16 EP claimed
US-4088786-A Method for utilizing tetrahydro-4-imino-1-naphthylureas as growth promoting agents for animals AMERICAN CYANAMID COMPANY (US) 1978-05-09 US claimed
US-3982999-A LEUKEMIA KHARASCH JEROME A 1976-09-28 US claimed