Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.60 |
| ▸ | LIPE | Q05469 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30597555 | 0.90 | MAPT (0.68) | MAPTEPHX2SMN1; SMN2LMNAKDM4E | |
| SCHEMBL30597528 | 0.89 | MAPT (0.73) | MAPTSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL30597496 | 0.88 | EPHX2 (0.60) | MAPTEPHX2LIPESMN1; SMN2LMNA | |
| SCHEMBL30597532 | 0.87 | MAPT (0.70) | MAPTEPHX2SMN1; SMN2LMNAKDM4E | |
| SCHEMBL30597557 | 0.85 | MAPT (0.65) | MAPTSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL30597510 | 0.85 | MAPT (0.65) | MAPTSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL30597511 | 0.84 | MAPT (0.67) | MAPTEPHX2SMN1; SMN2LMNAKDM4E | |
| SCHEMBL30597508 | 0.84 | MAPT (0.66) | MAPTEPHX2SMN1; SMN2LMNAKDM4E | |
| SCHEMBL30597537 | 0.83 | MAPT (0.63) | MAPTSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL30597504 | 0.83 | MAPT (0.63) | MAPTSMN1; SMN2LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023201014-A1 | BENZOTHIAZOLE-PHENYLSULFONYL-PIPERIDINE ANALOGS AS ACTIVATORS OF N-ACYLPHOSPHATIDYLETHANOLAMINE HYDROLYZING PHOSPHOLIPASE D | VANDERBILT UNIVERSITY (US) | 2023-10-19 | — | — | WO | claimed |
| WO-2023201014-A1 | BENZOTHIAZOLE-PHENYLSULFONYL-PIPERIDINE ANALOGS AS ACTIVATORS OF N-ACYLPHOSPHATIDYLETHANOLAMINE HYDROLYZING PHOSPHOLIPASE D | VANDERBILT UNIVERSITY (US) | 2023-10-19 | — | — | WO | disclosed |