Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.85 |
| ▸ | RAB9A | P51151 | 4/20 | 0.85 |
| ▸ | MEN1 | O00255 | 4/20 | 0.85 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | SNCA | P37840 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26458871 | 0.92 | NPC1 (1.00) | NPC1KMT2ARAB9AMEN1LCK | |
| SCHEMBL30597536 | 0.82 | NPC1 (0.64) | NPC1KMT2ARAB9AMEN1LCK | |
| SCHEMBL30597529 | 0.79 | KMT2A (0.69) | NPC1KMT2ARAB9AMEN1LCK | |
| SCHEMBL30597542 | 0.77 | KMT2A (0.67) | NPC1KMT2ARAB9AMEN1LCK | |
| SCHEMBL28530525 | 0.76 | KMT2A (0.67) | NPC1KMT2ARAB9AMEN1LCK | |
| SCHEMBL30944361 | 0.76 | KMT2A (0.67) | NPC1KMT2ARAB9AMEN1LCK | |
| SCHEMBL15274399 | 0.75 | KMT2A (0.66) | NPC1KMT2ARAB9AMEN1LCK | |
| SCHEMBL30597513 | 0.75 | MEN1 (0.63) | NPC1KMT2ARAB9AMEN1KDM4E | |
| SCHEMBL30597543 | 0.75 | MEN1 (0.63) | NPC1KMT2ARAB9AMEN1KDM4E | |
| SCHEMBL30597519 | 0.74 | MEN1 (0.62) | NPC1KMT2ARAB9AMEN1SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023201014-A1 | BENZOTHIAZOLE-PHENYLSULFONYL-PIPERIDINE ANALOGS AS ACTIVATORS OF N-ACYLPHOSPHATIDYLETHANOLAMINE HYDROLYZING PHOSPHOLIPASE D | VANDERBILT UNIVERSITY (US) | 2023-10-19 | — | — | WO | disclosed |