Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 7/20 | 0.71 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.71 |
| ▸ | BRD4 | O60885 | 5/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | BRD2 | P25440 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | XBP1 | P17861 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.52 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20291205 | 1.00 | HCRTR1 (0.71) | HCRTR1HCRTR2BRD4POLBBRD2 | |
| SCHEMBL20291072 | 0.90 | BRD4 (0.73) | HCRTR1HCRTR2BRD4POLBBRD2 | |
| SCHEMBL23787106 | 0.89 | BRD4 (0.72) | HCRTR1HCRTR2BRD4POLBBRD2 | |
| SCHEMBL20291414 | 0.86 | BRD4 (0.66) | HCRTR1HCRTR2BRD4HTTMAPT | |
| SCHEMBL20291227 | 0.85 | HCRTR1 (0.55) | HCRTR1HCRTR2BRD4BRD2MAPK1 | |
| SCHEMBL20291395 | 0.84 | HCRTR1 (0.56) | HCRTR1HCRTR2BRD4BRD2MAPT | |
| SCHEMBL20291390 | 0.83 | ALDH1A1 (0.65) | HCRTR1HCRTR2BRD4HTTMAPT | |
| SCHEMBL20291277 | 0.83 | BRD4 (0.57) | HCRTR1HCRTR2BRD4BRD2KMT2A | |
| SCHEMBL20291003 | 0.83 | BRD4 (0.60) | HCRTR1HCRTR2BRD4POLBBRD2 | |
| SCHEMBL30599699 | 0.83 | BRD4 (0.60) | HCRTR1HCRTR2BRD4POLBBRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3554503-B1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | UNIV TEXAS (US) | 2023-10-04 | — | — | EP | disclosed |