Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | PRNP | P04156 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34461950 | 0.83 | FFAR2 (0.41) | MAPTLMNATSHRHTTPRNP | |
| SCHEMBL24535994 | 0.81 | SMN1; SMN2 (0.44) | MAPTTSHRTP53HPGDSMN1; SMN2 | |
| SCHEMBL30886796 | 0.81 | SMN1; SMN2 (0.44) | MAPTTSHRTP53HPGDSMN1; SMN2 | |
| SCHEMBL25079054 | 0.81 | SMN1; SMN2 (0.44) | MAPTTSHRTP53HPGDSMN1; SMN2 | |
| SCHEMBL29680675 | 0.81 | SMN1; SMN2 (0.44) | MAPTTSHRTP53HPGDSMN1; SMN2 | |
| SCHEMBL24858311 | 0.79 | SMN1; SMN2 (0.42) | MAPTTP53HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL19719450 | 0.79 | HTT (0.52) | MAPTLMNATSHRHTTPRNP | |
| SCHEMBL17030840 | 0.77 | MAPT (0.57) | MAPTLMNATSHRHTTPRNP | |
| SCHEMBL25306753 | 0.75 | SRC (0.47) | MAPTLMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL31553945 | 0.75 | MAPT (0.50) | MAPTLMNATSHRHTTPRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12599672-B2 | KRAS proteolysis targeting chimeras | PAQ Therapeutics Inc. (US) | 2026-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12599672-B2 | KRAS proteolysis targeting chimeras | KRAS, HRAS, NRAS | MAPT 4616/4885LMNA 2281/4885TSHR 2601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.