Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 8/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.82 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28458738 | 0.97 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Bromide SCHEMBL80468 | 0.97 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Bromide SCHEMBL27692935 | 0.97 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL237898 | 0.97 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Bromide SCHEMBL27702129 | 0.97 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Bromide SCHEMBL3899568 | 0.97 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL2584895 | 0.94 | APOBEC3A (0.74) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Bromide SCHEMBL80467 | 0.94 | APOBEC3A (0.82) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL30862487 | 0.94 | APOBEC3A (0.82) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Bromide SCHEMBL10995902 | 0.94 | APOBEC3A (0.82) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132431-A1 | METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2024-04-25 | — | — | US | disclosed |
| EP-4279476-A1 | METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2023-11-22 | — | — | EP | disclosed |
| CN-116829524-A | Method for alkylating acidic functional groups | 中外制药株式会社 | 2023-09-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132431-A1 | METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP | MGMT, MCL1, FANCF | ACHE 2105/4885APOBEC3A 284/4885APOBEC3G 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.