Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1366474 | 1.00 | MAPK1 (0.33) | MAPK1NPC1HSP90AA1L3MBTL1 | |
| SCHEMBL21298439 | 0.77 | CCR1 (0.43) | NPC1HSP90AA1L3MBTL1 | |
| SCHEMBL3147594 | 0.74 | HSP90AA1 (0.45) | NPC1HSP90AA1L3MBTL1 | |
| SCHEMBL203305 | 0.71 | DYRK1A (0.41) | — | |
| SCHEMBL3395413 | 0.69 | HSP90AA1 (0.45) | NPC1HSP90AA1L3MBTL1 | |
| SCHEMBL14829208 | 0.69 | NQO2 (0.32) | — | |
| SCHEMBL14829196 | 0.69 | POLB (0.31) | — | |
| SCHEMBL3142470 | 0.69 | ERN1 (0.32) | MAPK1 | |
| SCHEMBL4149779 | 0.67 | CCR1 (0.64) | NPC1HSP90AA1L3MBTL1 | |
| SCHEMBL20699181 | 0.67 | MAPK1 (0.38) | MAPK1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117024411-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2026-05-19 | — | — | CN | disclosed |
| CN-110709392-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |