Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 4/20 | 0.37 |
| ▸ | CCR8 | P51685 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CCR5 | P51681 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18266935 | 0.80 | L3MBTL1 (0.48) | HSP90AA1L3MBTL1NPC1KDM4EPRMT5 | |
| SCHEMBL31330058 | 0.80 | KDM4E (0.44) | HSP90AA1L3MBTL1NPC1KDM4EPRMT5 | |
| SCHEMBL13309958 | 0.77 | HTT (0.46) | HSP90AA1L3MBTL1NPC1KDM4EPRMT5 | |
| SCHEMBL22595963 | 0.77 | PRMT5 (0.47) | HSP90AA1L3MBTL1NPC1KDM4EPRMT5 | |
| SCHEMBL23763083 | 0.77 | HSP90AA1 (0.45) | HSP90AA1L3MBTL1NPC1KDM4EPRMT5 | |
| SCHEMBL14036115 | 0.77 | KDM4E (0.39) | HSP90AA1L3MBTL1NPC1KDM4EPRMT5 | |
| SCHEMBL22792743 | 0.74 | HSP90AA1 (0.42) | HSP90AA1L3MBTL1NPC1KDM4EPRMT5 | |
| SCHEMBL3151475 | 0.74 | PDGFRB (0.43) | HSP90AA1L3MBTL1NPC1KDM4EPRMT5 | |
| SCHEMBL26920348 | 0.74 | ADRA2A (0.45) | HSP90AA1L3MBTL1NPC1KDM4ECCR1 | |
| SCHEMBL16541494 | 0.73 | NPC1 (0.41) | HSP90AA1L3MBTL1NPC1KDM4EPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233493-A1 | Macrolides | Pfizer Products Inc. (US) | 2010-09-29 | — | — | EP | disclosed |