Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.70 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20774676 | 1.00 | ROCK2 (0.70) | ROCK2ROCK1CHEK1AURKADAPK3 | |
| SCHEMBL20774574 | 0.90 | ROCK2 (0.70) | ROCK2ROCK1 | |
| SCHEMBL30611368 | 0.90 | ROCK2 (0.70) | ROCK2ROCK1 | |
| SCHEMBL30611442 | 0.90 | ROCK2 (0.63) | ROCK2ROCK1WEE1ALK | |
| SCHEMBL20774807 | 0.90 | ROCK2 (0.63) | ROCK2ROCK1WEE1ALK | |
| SCHEMBL20774723 | 0.87 | ROCK2 (0.68) | ROCK2ROCK1 | |
| SCHEMBL30611372 | 0.87 | ROCK2 (0.68) | ROCK2ROCK1 | |
| SCHEMBL30611505 | 0.87 | ROCK2 (0.73) | ROCK2ROCK1 | |
| SCHEMBL20774625 | 0.87 | ROCK2 (0.73) | ROCK2ROCK1 | |
| SCHEMBL20774892 | 0.87 | ROCK2 (0.77) | ROCK2ROCK1CHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111587112-B | Rho-related inhibitors of coiled-coil-containing protein kinases | 卡德门企业有限公司 | 2023-10-10 | — | — | CN | disclosed |