Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20963871 | 1.00 | KDM4E (0.48) | KDM4EMAPTPOLBNPC1RAB9A | |
| SCHEMBL29278609 | 1.00 | KDM4E (0.48) | KDM4EMAPTPOLBNPC1RAB9A | |
| SCHEMBL14738759 | 0.85 | RXRA (0.45) | KDM4EMAPTNPC1RAB9ACA1 | |
| SCHEMBL6976229 | 0.85 | RXRA (0.45) | KDM4EMAPTNPC1RAB9ACA1 | |
| SCHEMBL30497213 | 0.85 | KDM4E (0.47) | KDM4EMAPTPOLBNPC1RAB9A | |
| SCHEMBL25301773 | 0.85 | KDM4E (0.47) | KDM4EMAPTPOLBNPC1RAB9A | |
| SCHEMBL14738760 | 0.85 | RXRA (0.45) | KDM4EMAPTNPC1RAB9ACA1 | |
| SCHEMBL20963587 | 0.84 | POLB (0.42) | KDM4EMAPTPOLBCA1CA2 | |
| SCHEMBL2698400 | 0.84 | GAA (0.50) | KDM4EMAPTNPC1RAB9AATM | |
| SCHEMBL2698398 | 0.84 | GAA (0.50) | KDM4EMAPTNPC1RAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704113-B1 | BRIDGED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-10-11 | — | — | EP | disclosed |