Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 16/20 | 0.82 |
| ▸ | MET | P08581 | 13/20 | 0.82 |
| ▸ | KDR | P35968 | 5/20 | 0.77 |
| ▸ | MERTK | Q12866 | 7/20 | 0.75 |
| ▸ | RET | P07949 | 4/20 | 0.64 |
| ▸ | KIT | P10721 | 4/20 | 0.64 |
| ▸ | FLT3 | P36888 | 4/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21200784 | 1.00 | AXL (0.82) | AXLMETKDRMERTKRET | |
| SCHEMBL21201112 | 0.92 | AXL (0.81) | AXLMETKDRMERTKRET | |
| SCHEMBL21201203 | 0.92 | AXL (0.74) | AXLMETKDRMERTKRET | |
| SCHEMBL30152436 | 0.91 | AXL (0.83) | AXLMETKDRMERTKRET | |
| SCHEMBL21200755 | 0.91 | AXL (0.83) | AXLMETKDRMERTKRET | |
| SCHEMBL30152581 | 0.91 | AXL (0.87) | AXLMETKDRMERTKRET | |
| SCHEMBL21201030 | 0.91 | AXL (0.87) | AXLMETKDRMERTKRET | |
| SCHEMBL30152509 | 0.91 | AXL (1.00) | AXLMETKDRMERTKRET | |
| SCHEMBL21200864 | 0.91 | AXL (1.00) | AXLMETKDRMERTKRET | |
| SCHEMBL21200722 | 0.88 | MET (0.82) | AXLMETKDRMERTKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117820226-A | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-117624045-A | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117603138-A | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-111757735-B | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2023-09-22 | — | — | CN | disclosed |