Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Bisphenol A. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | ESRRG | P62508 | 3/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | SHBG | P04278 | 1/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bisphenol A SCHEMBL22319407 | 0.93 | ESR1 (0.64) | ESR1ESR2CYP3A4ESRRGAR | |
| Bisphenol A SCHEMBL9147592 | 0.93 | ESR1 (0.64) | ESR1ESR2CYP3A4ESRRGAR | |
| Bisphenol A SCHEMBL4219076 | 0.93 | ESR1 (0.64) | ESR1ESR2CYP3A4ESRRGAR | |
| Bisphenol A SCHEMBL347900 | 0.93 | ESR1 (0.64) | ESR1ESR2CYP3A4ESRRGAR | |
| Methacrylic Acid SCHEMBL8843428 | 0.88 | ALDH1A1 (0.71) | ESR1ESR2CYP3A4ESRRGAR | |
| Bisphenol A SCHEMBL28626500 | 0.87 | ESR1 (0.51) | ESR1ESR2CYP3A4ESRRGAR | |
| Bisphenol A SCHEMBL28643426 | 0.87 | ESR1 (0.51) | ESR1ESR2CYP3A4ESRRGAR | |
| Bisphenol A SCHEMBL9418253 | 0.86 | ESR1 (0.47) | ESR1ESR2CYP3A4ESRRGAR | |
| Bisphenol A SCHEMBL28499285 | 0.85 | ESR1 (0.46) | ESR1ESR2CYP3A4ESRRGAR | |
| Bisphenol A SCHEMBL29707915 | 0.85 | ESR1 (0.46) | ESR1ESR2CYP3A4ESRRGAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12179450-B2 | Preparation method of PTFE-based nano functional composite membrane and use | CHINA THREE GORGES CORPORATION (CN) | 2024-12-31 | — | — | US | disclosed |
| US-20230330956-A1 | PREPARATION METHOD OF PTFE-BASED NANO FUNCTIONAL COMPOSITE MEMBRANE AND USE | CHINA THREE GORGES CORPORATION (CN) | 2023-10-19 | — | — | US | disclosed |