Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 15/20 | 0.36 |
| ▸ | F11 | P03951 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30271740 | 0.86 | F11 (0.33) | NOTUMF11RXRAGRIN1GRIN2B | |
| SCHEMBL30994997 | 0.83 | F11 (0.39) | NOTUMF11ARKLK1 | |
| SCHEMBL29227930 | 0.83 | F11 (0.39) | NOTUMF11ARKLK1 | |
| SCHEMBL31174128 | 0.82 | F11 (0.38) | NOTUMF11ARKLK1 | |
| SCHEMBL16971695 | 0.79 | F11 (0.39) | NOTUMF11 | |
| SCHEMBL31174077 | 0.79 | F11 (0.39) | NOTUMF11ARKLK1RXRA | |
| SCHEMBL16972063 | 0.78 | AR (0.38) | NOTUMF11ARKLK1 | |
| SCHEMBL31174109 | 0.77 | F11 (0.37) | NOTUMF11ARKLK1 | |
| SCHEMBL31174114 | 0.76 | NOTUM (0.38) | NOTUMF11ARKLK1RXRA | |
| SCHEMBL31174085 | 0.76 | F11 (0.41) | NOTUMF11ARKLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116987080-A | Macrocyclic compounds with heterocyclic P2' groups as factor XIA inhibitors | 百时美施贵宝公司 | 2023-11-03 | — | — | CN | disclosed |