Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 4/20 | 0.32 |
| ▸ | ITK | Q08881 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 6/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | BLK | P51451 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26645465 | 1.00 | JAK3 (0.34) | JAK3JAK2JAK1TYK2FLT3 | |
| SCHEMBL26644839 | 0.89 | JAK3 (0.40) | JAK3BTKCSNK1DCSNK1E | |
| SCHEMBL30622311 | 0.89 | JAK3 (0.40) | JAK3BTKCSNK1DCSNK1E | |
| SCHEMBL30622354 | 0.86 | BTK (0.38) | JAK3JAK2JAK1TYK2FLT3 | |
| SCHEMBL26645352 | 0.85 | BTK (0.41) | JAK3JAK2JAK1TYK2FLT3 | |
| SCHEMBL30622371 | 0.85 | BTK (0.41) | JAK3JAK2JAK1TYK2FLT3 | |
| SCHEMBL26644870 | 0.85 | LIMK1 (0.37) | JAK3JAK2JAK1TYK2FLT3 | |
| SCHEMBL30622420 | 0.85 | LIMK1 (0.37) | JAK3JAK2JAK1TYK2FLT3 | |
| SCHEMBL30622901 | 0.85 | CSNK1E (0.33) | CSNK1DCSNK1E | |
| SCHEMBL26645485 | 0.85 | CSNK1E (0.33) | CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519265-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | Bayer Aktiengesellschaft (DE) | 2025-03-12 | — | — | EP | claimed |
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | claimed |
| EP-4519265-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | Bayer Aktiengesellschaft (DE) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |