Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 10/20 | 0.42 |
| ▸ | HTR2C | P28335 | 6/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25359279 | 1.00 | MAPK1 (0.42) | MAPK1RECQLDRD4HTR2CDRD2 | |
| SCHEMBL25357626 | 0.94 | MAPK1 (0.41) | MAPK1RECQLDRD4HTR2CDRD2 | |
| SCHEMBL30623449 | 0.94 | MAPK1 (0.41) | MAPK1RECQLDRD4HTR2CDRD2 | |
| SCHEMBL30623434 | 0.92 | MAPK1 (0.41) | MAPK1RECQLDRD4HTR2CDRD2 | |
| SCHEMBL25358042 | 0.92 | MAPK1 (0.41) | MAPK1RECQLDRD4HTR2CDRD2 | |
| SCHEMBL25356801 | 0.87 | DRD4 (0.52) | MAPK1RECQLDRD4HTR2CDRD2 | |
| SCHEMBL30623379 | 0.87 | DRD4 (0.52) | MAPK1RECQLDRD4HTR2CDRD2 | |
| SCHEMBL26012504 | 0.87 | DRD4 (0.52) | MAPK1RECQLDRD4HTR2CDRD2 | |
| SCHEMBL25360278 | 0.86 | SIGMAR1 (0.44) | MAPK1RECQLDRD4HTR2CDRD2 | |
| SCHEMBL30623412 | 0.86 | SIGMAR1 (0.44) | MAPK1RECQLDRD4HTR2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4476207-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | Vertex Pharmaceuticals Incorporated (US) | 2024-12-18 | — | — | EP | disclosed |
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |