Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3067892 | 0.88 | TOP2A (0.52) | TOP2A | |
| SCHEMBL3074718 | 0.86 | TOP2A (0.43) | TOP2A | |
| SCHEMBL3074937 | 0.86 | TOP2A (0.45) | TOP2A | |
| SCHEMBL3068279 | 0.85 | TOP2A (0.48) | TOP2A | |
| SCHEMBL3186315 | 0.82 | TOP2A (0.46) | TOP2A | |
| SCHEMBL3073378 | 0.81 | TOP2A (0.49) | TOP2A | |
| SCHEMBL3069138 | 0.81 | TOP2A (0.44) | TOP2A | |
| SCHEMBL3073461 | 0.80 | TOP2A (0.48) | TOP2A | |
| SCHEMBL13268318 | 0.80 | TOP2A (0.51) | TOP2A | |
| SCHEMBL3062640 | 0.80 | TOP2A (0.46) | TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261719-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261719-A1 | CHEMICAL COMPOUNDS | NCOA3, NR4A3, NR0B2 | TOP2A 1313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.