SCHEMBL30628131

SCHEMBL30628131

NS(=O)(=O)NCCNC(=O)c1cnon1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.41
KMT2A Q03164 4/20 0.35
CA1 P00915 6/20 0.34
CA2 P00918 6/20 0.34
CA12 O43570 5/20 0.34
CA4 P22748 4/20 0.34
CA9 Q16790 4/20 0.34
CA14 Q9ULX7 4/20 0.34
CA3 P07451 3/20 0.34
CA6 P23280 3/20 0.34
CA5A P35218 3/20 0.34
CA7 P43166 3/20 0.34
CA13 Q8N1Q1 3/20 0.34
CA5B Q9Y2D0 3/20 0.34
MAOB P27338 1/20 0.34
MALT1 Q9UDY8 1/20 0.34
ACACB O00763 1/20 0.33
ALDH1A1 P00352 1/20 0.32
RCE1 Q9Y256 1/20 0.32
KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10245956 0.75 SMN1; SMN2 (0.49) KMT2AALDH1A1KDM4E
SCHEMBL28300076 0.72 CA2 (0.42) IDO1CA1CA2CA12CA9
SCHEMBL26614278 0.65 CA1 (0.44) IDO1CA1CA2CA12CA9
SCHEMBL1012552 0.59
Ethylene SCHEMBL11862146 0.58 CA2 (0.57) CA1CA2CA12CA9CA14
SCHEMBL3014275 0.57 CA2 (0.44) KMT2ACA1CA2CA12CA4
SCHEMBL11188780 0.57
SCHEMBL7109274 0.57 CNR1 (0.50) KMT2AALDH1A1KDM4E
SCHEMBL19881760 0.57 IDO1 (0.48) IDO1
SCHEMBL2422789 0.56 CA2 (0.50) KMT2ACA1CA2CA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109897011-B IDO inhibitor and application thereof 上海华汇拓医药科技有限公司 2023-10-31 CN disclosed