Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.45 |
| ▸ | PLK4 | O00444 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | MARK3 | P27448 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26686302 | 1.00 | JAK2 (0.46) | JAK2JAK1MAPK1PLK4AURKB | |
| SCHEMBL26686360 | 0.88 | KDR (0.52) | JAK2JAK1MAPK1MAPTKDR | |
| SCHEMBL30633321 | 0.88 | KDR (0.52) | JAK2JAK1MAPK1MAPTKDR | |
| SCHEMBL26686141 | 0.85 | JAK2 (0.45) | JAK2JAK1MAPK1DYRK1ACYP3A4 | |
| SCHEMBL30633313 | 0.85 | JAK2 (0.45) | JAK2JAK1MAPK1DYRK1ACYP3A4 | |
| SCHEMBL30633312 | 0.85 | JAK2 (0.45) | JAK2JAK1MAPK1DYRK1ASMN1; SMN2 | |
| SCHEMBL30633352 | 0.83 | JAK2 (0.56) | JAK2JAK1MAPK1PLK4AURKB | |
| SCHEMBL31240315 | 0.83 | MAPK1 (0.56) | JAK2MAPK1PLK4AURKBGSK3A | |
| SCHEMBL26685764 | 0.83 | MAPK1 (0.56) | JAK2MAPK1PLK4AURKBGSK3A | |
| SCHEMBL26685861 | 0.83 | JAK2 (0.56) | JAK2JAK1MAPK1PLK4AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119562945-A | IKK inhibitors | 癌症研究技术有限公司 | 2025-03-04 | — | — | CN | claimed |
| EP-4522597-A1 | IKK INHIBITORS | Cancer Research Technology Limited (GB) | 2025-03-19 | — | — | EP | disclosed |
| CN-119562945-A | IKK inhibitors | 癌症研究技术有限公司 | 2025-03-04 | — | — | CN | disclosed |
| WO-2023218201-A1 | IKK INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2023-11-16 | — | — | WO | disclosed |