Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.37 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30412718 | 1.00 | ALK (0.43) | ALKGPR119HDAC1MAPK8LRRK2 | |
| SCHEMBL30635607 | 0.91 | ALK (0.44) | ALKGPR119HDAC1MAPK8LRRK2 | |
| SCHEMBL30412450 | 0.90 | ALK (0.43) | ALKGPR119HDAC1MAPK8LRRK2 | |
| SCHEMBL30410928 | 0.90 | ALK (0.43) | ALKGPR119HDAC1MAPK8LRRK2 | |
| SCHEMBL10205822 | 0.90 | ALK (0.54) | ALKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL25198593 | 0.90 | PTK2 (0.40) | ALKLRRK2FLT4PTK2 | |
| SCHEMBL26629481 | 0.90 | PTK2 (0.40) | ALKLRRK2FLT4PTK2 | |
| SCHEMBL30412211 | 0.90 | ALK (0.42) | ALKGPR119HDAC1LRRK2FLT4 | |
| SCHEMBL30635547 | 0.90 | ALK (0.42) | ALKGPR119HDAC1LRRK2FLT4 | |
| SCHEMBL30635665 | 0.88 | ALK (0.48) | ALKEGFRERBB2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |