⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020060 | 1.00 | — | — | |
| SCHEMBL1405790 | 1.00 | — | — | |
| SCHEMBL8893405 | 0.87 | SLC22A6 (0.57) | — | |
| SCHEMBL8893398 | 0.87 | SLC22A6 (0.57) | — | |
| SCHEMBL8893395 | 0.87 | SLC22A6 (0.57) | — | |
| SCHEMBL112368 | 0.81 | SLC22A6 (1.00) | — | |
| SCHEMBL30496763 | 0.81 | SLC22A6 (1.00) | — | |
| SCHEMBL8893746 | 0.79 | SLC22A6 (0.42) | — | |
| SCHEMBL8893755 | 0.79 | SLC22A6 (0.42) | — | |
| SCHEMBL6733935 | 0.78 | SLC22A6 (0.93) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213354-B1 | Process for producing optically active 4-halo-3-hydroxybutanoate | SUMITOMO CHEMICAL CO (JP) | 2007-05-30 | — | — | EP | claimed |
| US-6884607-B2 | Process for producing optically active 4-halo-3-hydroxybutanoate | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-04-26 | — | — | US | claimed |
| US-20050019816-A1 | Process for producing optically active-4-halo-3-hydroxybutanoate | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-01-27 | — | — | US | claimed |
| US-20030134402-A1 | Process for producing optically active 4-halo-3-hydroxybutanoate | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-07-17 | — | — | US | claimed |
| EP-1213354-A2 | Process for producing optically active 4-halo-3-hydroxybutanoate | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-06-12 | — | — | EP | claimed |
| EP-0643689-B1 | IMPROVED PROCESS FOR THE SYNTHESIS OF (5R)-1,1-DIMETHYLETHYL 6-CYANO-5-HYDROXY-3-OXO-HEXANOATE | WARNER LAMBERT CO (US) | 1998-12-30 | — | — | EP | claimed |
| EP-0643689-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF (5R)-1,1-DIMETHYLETHYL 6-CYANO-5-HYDROXY-3-OXO-HEXANOATE | WARNER-LAMBERT COMPANY (US) | 1995-03-22 | — | — | EP | claimed |
| WO-1993007115-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF (5R)-1,1-DIMETHYLETHYL 6-CYANO-5-HYDROXY-3-OXO-HEXANOATE | WARNER-LAMBERT COMPANY (US) | 1993-04-15 | — | — | WO | claimed |
| US-5155251-A | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate | WARNER-LAMBERT COMPANY (US) | 1992-10-13 | — | — | US | claimed |
| CN-104370953-B | (R)-tert-butyl dimethyl siloxy-glutaric acid monoester preparation method | 浙江新东港药业股份有限公司 | 2017-01-18 | — | — | CN | disclosed |
| CN-104370953-A | (R)-tert-butyl dimethyl siloxy-glutaric acid monoester preparation method | ZHEJIANG NEO DANKONG PHARMACEUTICAL CO LTD | 2015-02-25 | — | — | CN | disclosed |
| CN-101367780-B | Joint production method for (S)-3-hydroxyl-gamma-butyrolactone, (S)-3-hydroxyl tetrahydrofuran | CHANGMAO BIOCHEMICAL ENGINEERING CO LTD | 2011-04-20 | — | — | CN | disclosed |
| US-20100261251-A1 | MICROBIAL KINETIC RESOLUTION OF ETHYL-3,4-EPOXYBUTYRATE | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-10-14 | — | — | US | disclosed |
| US-7807423-B2 | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives | CODEXIS, INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-5017716-A | 3-hydroxy-3-methylglutaryl-coenzyme a | E.R. SQUIBB & SONS, INC. (US) | 1991-05-21 | — | — | US | disclosed |
| US-4992429-A | Novel HMG-COA reductase inhibitors | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0356788-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| US-4904646-A | INHIBIT CHOLESTEROL BIOSYNTHESIS | E. R. SQUIBB & SONS, INC. (US) | 1990-02-27 | — | — | US | disclosed |
| CN-1030761-A | Phosphorated 3-hydroxyl-3-first glutaryl CoA-reductase inhibitors, new intermediate and method | SQUIBB & SONS INC (US) | 1989-02-01 | — | — | CN | disclosed |
| CN-88103091-A | Phosphorous HMG-COA reductase inhibitor, new intermediate and using method | SQUIBB & SONS INC (US) | 1988-12-21 | — | — | CN | disclosed |