Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2702769 | 1.00 | KMT2A (0.54) | KMT2AMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL30354796 | 0.85 | KMT2A (0.45) | KMT2AMAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL25384763 | 0.85 | KMT2A (0.45) | KMT2AMAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL5569289 | 0.84 | KMT2A (0.55) | KMT2AMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL21835362 | 0.83 | MAPT (0.52) | KMT2AMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL29780767 | 0.83 | MAPT (0.58) | KMT2AMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL215759 | 0.83 | MAPT (0.58) | KMT2AMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL30218362 | 0.83 | MAPT (0.58) | KMT2AMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL11241454 | 0.81 | CYP19A1 (0.60) | KMT2AMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL3993993 | 0.81 | MAPT (0.56) | KMT2AMAPTLMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026056-A2 | HETEROARYL COMPOUNDS AS EGFR INHIBITORS AND THEIR USES | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| CN-116655599-A | Synthesis and application of EGFR allosteric inhibitors | 江南大学 | 2023-08-29 | — | — | CN | disclosed |