Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 13/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24807308 | 0.78 | MAT2A (0.63) | MAT2ATP53SMN1; SMN2LMNAKDM4E | |
| SCHEMBL24808398 | 0.77 | MAT2A (0.62) | MAT2ATP53SMN1; SMN2LMNAPARP1 | |
| SCHEMBL30095578 | 0.77 | MAT2A (0.62) | MAT2ATP53SMN1; SMN2LMNAPARP1 | |
| SCHEMBL24807047 | 0.77 | MAT2A (0.62) | MAT2ATP53SMN1; SMN2LMNAPARP1 | |
| SCHEMBL29161500 | 0.77 | MAT2A (0.62) | MAT2ASMN1; SMN2LMNAPARP1KDM4E | |
| SCHEMBL12322576 | 0.76 | MAT2A (0.60) | MAT2ATP53SMN1; SMN2LMNAPARP1 | |
| SCHEMBL14347575 | 0.75 | MAT2A (0.60) | MAT2ATP53SMN1; SMN2LMNAPARP1 | |
| SCHEMBL14374256 | 0.75 | MAT2A (0.66) | MAT2ATP53SMN1; SMN2LMNAPARP1 | |
| SCHEMBL11756495 | 0.73 | MAT2A (0.58) | MAT2ATP53SMN1; SMN2LMNAPRMT5 | |
| SCHEMBL24808403 | 0.72 | MAT2A (0.54) | MAT2ALMNAKDM4EMEN1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117624063-A | Heterocyclic compound and application thereof | 中国科学院上海药物研究所 | 2024-03-01 | — | — | CN | disclosed |
| WO-2023196985-A1 | METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-10-12 | — | — | WO | disclosed |