Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.66 |
| ▸ | EPHA2 | P29317 | 15/20 | 0.54 |
| ▸ | KDR | P35968 | 13/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.54 |
| ▸ | FLT1 | P17948 | 10/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | YES1 | P07947 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | HCK | P08631 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30640277 | 0.88 | EGFR (0.70) | EGFREPHA2KDRERBB2EPHB4 | |
| SCHEMBL6800284 | 0.86 | EGFR (0.55) | EGFREPHA2KDRERBB2EPHB4 | |
| SCHEMBL6795098 | 0.84 | EGFR (0.58) | EGFREPHA2KDRERBB2EPHB4 | |
| SCHEMBL6794421 | 0.84 | EGFR (0.63) | EGFREPHA2KDRERBB2EPHB4 | |
| SCHEMBL6789452 | 0.82 | EGFR (0.50) | EGFREPHA2ERBB2EPHB4 | |
| SCHEMBL30640367 | 0.82 | EGFR (0.56) | EGFREPHA2KDRERBB2EPHB4 | |
| SCHEMBL6794957 | 0.82 | EGFR (0.57) | EGFREPHA2KDRERBB2EPHB4 | |
| SCHEMBL6793039 | 0.81 | EGFR (0.61) | EGFREPHA2KDRERBB2FLT1 | |
| SCHEMBL30640332 | 0.81 | EGFR (0.59) | EGFRKDRERBB2EPHB4RIPK2 | |
| SCHEMBL20865233 | 0.80 | EGFR (1.00) | EGFREPHA2KDRERBB2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112079830-B | Inhibitor containing fused ring derivative, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-12-22 | — | — | CN | disclosed |