Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26621986 | 1.00 | MAPT (0.49) | MAPTKDM4ETDP1RAB9APTPN2 | |
| SCHEMBL21230507 | 0.88 | MAPT (0.49) | MAPTKDM4ETDP1RAB9APTPN2 | |
| SCHEMBL31550152 | 0.87 | PTPN2 (0.51) | MAPTKDM4ETDP1RAB9APTPN2 | |
| SCHEMBL26622014 | 0.87 | MAPT (0.48) | MAPTKDM4ETDP1RAB9APTPN2 | |
| SCHEMBL31550139 | 0.87 | MAPT (0.48) | MAPTKDM4ETDP1RAB9APTPN2 | |
| SCHEMBL12135685 | 0.85 | XDH (0.49) | MAPTKDM4ERAB9APTPN2L3MBTL1 | |
| SCHEMBL31550207 | 0.85 | PTPN2 (0.49) | MAPTKDM4ETDP1RAB9APTPN2 | |
| SCHEMBL31550135 | 0.83 | MAPT (0.46) | MAPTKDM4ETDP1RAB9APTPN2 | |
| SCHEMBL31550113 | 0.82 | PTPN2 (0.53) | MAPTKDM4ETDP1RAB9APTPN2 | |
| SCHEMBL31550161 | 0.81 | PTPN2 (0.46) | MAPTKDM4ETDP1RAB9APTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023214325-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND USES THEREOF AS TET2 INHIBITORS | NOVARTIS AG (CH) | 2023-11-09 | — | — | WO | disclosed |