Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21339930 | 0.82 | CHRM1 (0.52) | KDRCHRM1PSMB8MAP4K4HDAC1 | |
| SCHEMBL31341194 | 0.81 | HDAC1 (0.59) | KDRCHRM1PSMB8MAP4K4HDAC1 | |
| SCHEMBL31341086 | 0.81 | HDAC1 (0.59) | CHRM1PSMB8HDAC1HDAC3HDAC2 | |
| SCHEMBL31341277 | 0.81 | HDAC1 (0.59) | CHRM1PSMB8HDAC1HDAC3HDAC2 | |
| SCHEMBL31341204 | 0.80 | HDAC1 (0.58) | CHRM1HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL26673835 | 0.79 | KDR (0.60) | KDR | |
| SCHEMBL31341081 | 0.79 | HDAC1 (0.57) | KDRCHRM1PSMB8HDAC1HDAC3 | |
| SCHEMBL31341201 | 0.78 | MAPT (0.57) | CHRM1HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL30640603 | 0.77 | MAP4K4 (0.52) | CHRM1PSMB8MAP4K4HDAC1HDAC3 | |
| SCHEMBL30640602 | 0.77 | MAP4K4 (0.52) | CHRM1PSMB8MAP4K4HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250257041-A1 | INDUCERS OF INTEGRATED STRESS RESPONSE TO TREAT CANCER | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2025-08-14 | — | — | US | disclosed |
| EP-4526291-A1 | INDUCERS OF INTEGRATED STRESS RESPONSE TO TREAT CANCER | The Board of Regents of the University of Texas System (US) | 2025-03-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250257041-A1 | INDUCERS OF INTEGRATED STRESS RESPONSE TO TREAT CANCER | DDIT3, ATF4, EIF2AK3 | KDR 4758/4885CHRM1 4884/4885PSMB8 690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.