Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 2/20 | 0.34 |
| ▸ | FNTB | P49356 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16099983 | 1.00 | KRAS (0.45) | KRASIRAK4FNTAFNTBIDO1 | |
| SCHEMBL16122588 | 0.88 | KRAS (0.44) | KRASFNTAFNTBUSP30MEN1 | |
| SCHEMBL30642257 | 0.88 | KRAS (0.44) | KRASFNTAFNTBUSP30MEN1 | |
| SCHEMBL16098252 | 0.86 | KRAS (0.48) | KRASIRAK4FNTAFNTB | |
| SCHEMBL16129263 | 0.81 | KRAS (0.68) | KRASFNTAFNTBUSP30MEN1 | |
| SCHEMBL30642306 | 0.81 | KRAS (0.68) | KRASFNTAFNTBUSP30MEN1 | |
| SCHEMBL16093602 | 0.77 | KRAS (0.46) | KRAS | |
| SCHEMBL30642275 | 0.77 | KRAS (0.48) | KRASMEN1KMT2A | |
| SCHEMBL16098954 | 0.77 | KRAS (0.48) | KRASMEN1KMT2A | |
| SCHEMBL16102313 | 0.77 | KRAS (0.46) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE50527-E1 | Covalent inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2025-08-12 | — | — | US | disclosed |
| EP-3401314-B1 | COVALENT INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC (US) | 2023-11-08 | — | — | EP | disclosed |