Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.72 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3049471 | 0.89 | REV1 (0.71) | REV1CHRNA7ABCB1KDM4EABCC1 | |
| SCHEMBL3058969 | 0.89 | REV1 (0.71) | REV1CHRNA7ABCB1KDM4EABCC1 | |
| SCHEMBL3059193 | 0.88 | REV1 (0.87) | REV1CHRNA7ABCB1KDM4EABCC1 | |
| SCHEMBL3059849 | 0.87 | REV1 (0.74) | REV1CHRNA7ABCB1KDM4EABCC1 | |
| SCHEMBL3050371 | 0.87 | REV1 (0.84) | REV1CHRNA7ABCB1KDM4EABCC1 | |
| SCHEMBL3052241 | 0.86 | REV1 (0.76) | REV1CHRNA7ABCB1KDM4EABCC1 | |
| SCHEMBL3057822 | 0.85 | REV1 (0.66) | REV1CHRNA7ABCB1KDM4EABCC1 | |
| SCHEMBL3059243 | 0.85 | REV1 (0.78) | REV1CHRNA7ABCB1KDM4EABCC1 | |
| SCHEMBL3059563 | 0.83 | REV1 (0.66) | REV1CHRNA7ABCB1KDM4EABCC1 | |
| SCHEMBL3059029 | 0.83 | REV1 (0.62) | REV1CHRNA7ABCB1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | claimed |
| US-8394825-B2 | Compound | STERIX LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | disclosed |
| EP-2155192-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | Sterix Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008117061-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222299-A1 | COMPOUND | MKI67, VHL, MYC | REV1 1520/4885CHRNA7 4760/4885ABCB1 754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.