Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 7/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.42 |
| ▸ | CYP24A1 | Q07973 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30646096 | 0.85 | MELK (0.35) | CYP26A1CYP19A1CYP24A1DHODHCYP27A1 | |
| SCHEMBL30646127 | 0.82 | CYP19A1 (0.37) | CYP26A1CYP19A1DDB1CRBNDHODH | |
| SCHEMBL30646108 | 0.79 | MELK (0.34) | DHODH | |
| SCHEMBL4432336 | 0.73 | CYP26A1 (0.38) | CYP26A1CYP19A1CYP24A1DHODHCYP27A1 | |
| SCHEMBL30646131 | 0.68 | GRM5 (0.44) | DHODH | |
| SCHEMBL8158688 | 0.67 | CYP26A1 (0.86) | CYP26A1CYP19A1CYP24A1HTR1ASIGMAR1 | |
| SCHEMBL8465475 | 0.65 | CYP19A1 (0.78) | CYP26A1CYP19A1CYP24A1HTR1ASIGMAR1 | |
| SCHEMBL4419499 | 0.64 | CYP19A1 (0.38) | CYP26A1CYP19A1CYP24A1DDB1CRBN | |
| SCHEMBL4433213 | 0.64 | CYP24A1 (0.43) | CYP26A1CYP19A1CYP24A1MAOBDHODH | |
| SCHEMBL3761876 | 0.63 | CYP19A1 (0.80) | CYP26A1CYP19A1MAOBDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543437-A1 | 3-?HSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF | THE CLEVELAND CLINIC FOUNDATION (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2023250480-A1 | 3-βHSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF | THE CLEVELAND CLINIC FOUNDATION (US) | 2023-12-28 | — | — | WO | disclosed |