Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18696150 | 0.88 | CDC7 (0.43) | NOTUMDYRK1AKDM4EALDH1A1ATM | |
| SCHEMBL6988092 | 0.86 | DYRK1A (0.62) | NOTUMDYRK1AKDM4EALDH1A1NAPRT | |
| SCHEMBL28975479 | 0.79 | MAPT (0.39) | DYRK1AALDH1A1ATMPOLBKMT2A | |
| SCHEMBL31702834 | 0.78 | NOTUM (0.50) | NOTUMDYRK1AKDM4EALDH1A1NAPRT | |
| SCHEMBL18584787 | 0.78 | CDC7 (0.36) | NOTUMDYRK1AALDH1A1ATMCDC7 | |
| SCHEMBL20494535 | 0.77 | NOTUM (0.48) | NOTUMDYRK1AKDM4EHTTKMT2A | |
| SCHEMBL21086635 | 0.74 | DYRK1A (0.40) | DYRK1AKDM4EALDH1A1ATMNAPRT | |
| SCHEMBL5190778 | 0.74 | ERCC1 (0.53) | DYRK1AKDM4EALDH1A1ATMCDC7 | |
| SCHEMBL16918372 | 0.74 | DAO (0.53) | DYRK1AKDM4EALDH1A1ATMDHODH | |
| SCHEMBL29159168 | 0.74 | SMN1; SMN2 (0.56) | NOTUMALDH1A1DHODHPOLBMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137542-B | Pyridone dicarboxamides as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2023-10-27 | — | — | CN | disclosed |