Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30647261 | 0.86 | NOTUM (0.48) | DYRK1ANOTUMKDM4ENAPRTKDM3B | |
| SCHEMBL31702834 | 0.83 | NOTUM (0.50) | DYRK1ANOTUMKDM4ENAPRTHPGD | |
| SCHEMBL10686600 | 0.81 | KDM4E (0.51) | DYRK1AKDM4ENAPRTHSD17B10ALDH1A1 | |
| SCHEMBL20494535 | 0.81 | NOTUM (0.48) | DYRK1ANOTUMKDM4EKMT2A | |
| SCHEMBL6208318 | 0.78 | NOTUM (0.54) | DYRK1ANOTUMKDM4EHPGDHSD17B10 | |
| SCHEMBL4037213 | 0.77 | PKM (0.54) | DYRK1ANOTUMKDM4EKDM3BSMN1; SMN2 | |
| SCHEMBL22114512 | 0.77 | NOTUM (0.52) | DYRK1ANOTUMKDM4EHPGDHSD17B10 | |
| SCHEMBL2704343 | 0.77 | NOTUM (0.52) | DYRK1ANOTUMKDM4EHPGDKDM3B | |
| SCHEMBL480033 | 0.77 | NOTUM (0.63) | DYRK1ANOTUMKDM4EHPGDHSD17B10 | |
| SCHEMBL4542707 | 0.77 | NOTUM (0.52) | DYRK1ANOTUMCSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362033-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064568-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |
| US-20250388543-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250388543-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | SCN8A, SCN1B, SCN3A | DYRK1A 3125/4885NOTUM 3371/4885KDM4E 4442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.