Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21265437 | 1.00 | STAT6 (0.53) | STAT6MKNK1SYKCSF1RMKNK2 | |
| SCHEMBL30647405 | 0.91 | CAMK2D (0.47) | STAT6MKNK1SYKCSF1RMKNK2 | |
| SCHEMBL21265513 | 0.91 | CAMK2D (0.47) | STAT6MKNK1SYKCSF1RMKNK2 | |
| SCHEMBL21265490 | 0.90 | JAK2 (0.56) | STAT6MKNK1SYKFLT3PLK4 | |
| SCHEMBL30647365 | 0.90 | JAK2 (0.56) | STAT6MKNK1SYKFLT3PLK4 | |
| SCHEMBL21247002 | 0.90 | MAPK8 (0.56) | MKNK1CSF1RMKNK2FLT3CDK4 | |
| SCHEMBL30647389 | 0.90 | MAPK8 (0.56) | MKNK1CSF1RMKNK2FLT3CDK4 | |
| SCHEMBL21265792 | 0.89 | MKNK1 (0.62) | STAT6MKNK1SYKCSF1RMKNK2 | |
| SCHEMBL30647390 | 0.89 | MKNK1 (0.62) | STAT6MKNK1SYKCSF1RMKNK2 | |
| SCHEMBL21265796 | 0.89 | CDK4 (0.49) | STAT6CDK4CDK6CCNT1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111566100-B | Pyrimidine compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2023-10-27 | — | — | CN | disclosed |