Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26640288 | 1.00 | MAPT (0.55) | MAPTCDK5CDK5R1MAPK1GPR119 | |
| SCHEMBL26640906 | 0.91 | MAPT (0.62) | MAPTMAPK1GPR119KDRPDGFRB | |
| SCHEMBL26640680 | 0.88 | MAPT (0.55) | MAPTCDK5CDK5R1MAPK1KDR | |
| SCHEMBL30648697 | 0.88 | MAPT (0.55) | MAPTCDK5CDK5R1MAPK1KDR | |
| SCHEMBL26640195 | 0.88 | MAPT (0.56) | MAPTCDK5CDK5R1MAPK1GPR119 | |
| SCHEMBL30648720 | 0.88 | MAPT (0.56) | MAPTCDK5CDK5R1MAPK1GPR119 | |
| SCHEMBL26640978 | 0.88 | CDK2 (0.53) | MAPTCDK5CDK5R1MAPK1KDR | |
| SCHEMBL30648854 | 0.88 | CDK2 (0.53) | MAPTCDK5CDK5R1MAPK1KDR | |
| SCHEMBL26640350 | 0.87 | MAPT (0.54) | MAPTMAPK1GPR119KDRPDGFRB | |
| SCHEMBL30648637 | 0.87 | MAPT (0.53) | MAPTCDK5CDK5R1MAPK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |