Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 7/20 | 0.46 |
| ▸ | JAK3 | P52333 | 6/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26640195 | 1.00 | MAPT (0.56) | MAPTGPR119CDK2CCNT1CDK1 | |
| SCHEMBL26640599 | 0.89 | MAPT (0.65) | MAPTGPR119JAK2JAK3PTK2 | |
| SCHEMBL26640288 | 0.88 | MAPT (0.55) | MAPTGPR119CDK2CDK5CDK5R1 | |
| SCHEMBL30648780 | 0.88 | MAPT (0.55) | MAPTGPR119CDK2CDK5CDK5R1 | |
| SCHEMBL26640925 | 0.86 | MAPT (0.56) | MAPTCDK2KDRPDGFRBDDB1 | |
| SCHEMBL26640403 | 0.86 | MAPT (0.58) | MAPTCDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL30648732 | 0.86 | MAPT (0.58) | MAPTCDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL30648714 | 0.83 | MAPT (0.56) | MAPTCDK2CCNT1CCNA2CCND3 | |
| SCHEMBL26640628 | 0.83 | MAPT (0.56) | MAPTCDK2CCNT1CCNA2CCND3 | |
| SCHEMBL30648697 | 0.83 | MAPT (0.55) | MAPTCDK2CCNA2CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |