⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9805971 | 0.90 | — | — | |
| SCHEMBL6851018 | 0.79 | TSHR (0.46) | — | |
| SCHEMBL175104 | 0.79 | TSHR (0.46) | — | |
| SCHEMBL8899792 | 0.79 | TSHR (0.46) | — | |
| SCHEMBL8636559 | 0.71 | — | — | |
| SCHEMBL2120545 | 0.71 | LMNA (0.35) | — | |
| SCHEMBL23530156 | 0.71 | — | — | |
| SCHEMBL8414690 | 0.70 | — | — | |
| SCHEMBL9209674 | 0.70 | — | — | |
| SCHEMBL9212506 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166173-A | Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same | GUILFORD PHARMACEUTICALS INC. (US) | 2000-12-26 | — | — | US | claimed |
| US-20130023688-A1 | PHOSPHORUS-CONTAINING COMPOUNDS WITH POLYMERIC CHAINS, AND METHODS OF MAKING AND USING THE SAME | EISAI INC. (US) | 2013-01-24 | — | — | US | disclosed |
| US-8258255-B2 | Phosphorus-containing compounds with polymeric chains, and methods of making and using the same | EISAI INC. (US) | 2012-09-04 | — | — | US | disclosed |
| US-20100267924-A1 | Phosphorus-Containing Compounds with Polymeric Chains, and Methods of Making and Using the Same | EISAI INC. (US) | 2010-10-21 | — | — | US | disclosed |
| US-7674875-B2 | Phosphorus-containing compounds with polymeric chains, and methods of making and using the same | EISAI INC. (US) | 2010-03-09 | — | — | US | disclosed |
| US-20090247778-A1 | Star polymer such as of a polylactone based on a central phosphorus atom derived from phosphorus oxychloride (POCl3) or ethyl dichlorophosphate; biodegradable and/or biocompatible; sustained release drug delivery; reverse thermal gelation | EISAI CORPORATION OF NORTH AMERICA (US) | 2009-10-01 | — | — | US | disclosed |
| US-7479535-B2 | Phosphorous-containing compounds with polymeric chains, and methods of making and using the same | GUILFORD PHARMACEUTICALS, INC. (US) | 2009-01-20 | — | — | US | disclosed |
| US-7101568-B2 | Methods and compositions for treating solid tumors | GUILFORD PHARMACEUTICALS, INC. (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1140028-B1 | BIODEGRADABLE POLY(PHOSPHOESTER) COMPOSITIONS FOR TREATING OVARIAN CANCER | GUILFORD PHARM INC (US) | 2005-11-23 | — | — | EP | disclosed |
| US-20050238616-A1 | Compositions for treatment of central nervous system neoplasms, and methods of making and using the same | GUILFORD PHARMACEUTICALS, INC. (US) | 2005-10-27 | — | — | US | disclosed |
| US-20010038849-A1 | Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same | EISAI INC. | 2001-11-08 | — | — | US | disclosed |
| EP-1140028-A1 | METHODS FOR TREATING OVARIAN CANCER, POLY(PHOSPHOESTER) COMPOSITIONS, AND BIODEGRADABLE ARTICLES FOR SAME | GUILFORD PHARMACEUTICALS INC. (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1096957-A1 | METHODS AND REAGENTS FOR INTRAMUSCULAR DELIVERY OF NUCLEIC ACIDS | Johns Hopkins University School of Medicine (US) | 2001-05-09 | — | — | EP | disclosed |
| US-6166173-A | Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same | GUILFORD PHARMACEUTICALS INC. (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000057852-A2 | METHODS AND COMPOSITIONS FOR TREATING SOLID TUMORS | GUILFORD PHARMACEUTICALS, INC. (US) | 2000-10-05 | — | — | WO | disclosed |
| WO-2000041678-A1 | METHODS FOR TREATING OVARIAN CANCER, POLY(PHOSPHOESTER) COMPOSITIONS, AND BIODEGRADABLE ARTICLES FOR SAME | GUILFORD PHARMACEUTICALS INC. (US) | 2000-07-20 | — | — | WO | disclosed |
| WO-1999065531-A9 | POLYMERS FOR DELIVERY OF NUCLEIC ACIDS | UNIV JOHNS HOPKINS MED (US) | 2000-04-27 | — | — | WO | disclosed |
| EP-0971969-A1 | BIODEGRADABLE POLYMERS CHAIN-EXTENDED BY PHOSPHATES, COMPOSITIONS, ARTICLES AND METHODS FOR MAKING AND USING THE SAME | GUILFORD PHARMACEUTICALS INC. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1999065531-A1 | POLYMERS FOR DELIVERY OF NUCLEIC ACIDS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-12-23 | — | — | WO | disclosed |
| WO-1998044020-A1 | BIODEGRADABLE POLYMERS CHAIN-EXTENDED BY PHOSPHATES, COMPOSITIONS, ARTICLES AND METHODS FOR MAKING AND USING THE SAME | GUILFORD PHARMACEUTICALS INC. (US) | 1998-10-08 | — | — | WO | disclosed |