Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | CKS1B | P61024 | 1/20 | 0.47 |
| ▸ | SKP1 | P63208 | 1/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30657815 | 0.89 | PARP1 (0.52) | PARP1NAMPTKCNA3HDAC3HDAC1 | |
| SCHEMBL4616517 | 0.83 | NAMPT (0.69) | PARP1NAMPTKCNA3CKS1BSKP1 | |
| SCHEMBL30657812 | 0.82 | HTT (0.54) | PARP1NAMPTKCNA3CKS1BSKP1 | |
| SCHEMBL29979363 | 0.81 | NAMPT (0.65) | PARP1NAMPTKCNA3HDAC3HDAC1 | |
| SCHEMBL1271996 | 0.81 | CKS1B (0.55) | PARP1NAMPTKCNA3HDAC3HDAC1 | |
| SCHEMBL4960694 | 0.81 | POLB (0.58) | PARP1POLBKMT2AL3MBTL1MEN1 | |
| SCHEMBL12644375 | 0.81 | NAMPT (0.70) | PARP1NAMPTKCNA3CKS1BSKP1 | |
| SCHEMBL26641094 | 0.81 | POLB (0.55) | HSD11B1MGLLPOLBKMT2AL3MBTL1 | |
| SCHEMBL31267085 | 0.81 | PARP1 (0.53) | PARP1NAMPTKCNA3HDAC3HDAC1 | |
| SCHEMBL4700826 | 0.81 | PARP1 (0.50) | PARP1NAMPTKCNA3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260103458-A1 | Inhibitors of CDK8 and CDK19 | UNIV DUNDEE (GB) | 2026-04-16 | — | — | US | disclosed |
| EP-4519258-A1 | INHIBITORS OF CDK8 AND CDK19 | University of Dundee (GB) | 2025-03-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260103458-A1 | Inhibitors of CDK8 and CDK19 | CDK8, CDK18, CDK9 | PARP1 785/4885NAMPT 3017/4885KCNA3 3466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.